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Third dose of Moderna COVID-19 vaccine leads to 37-fold jump in antibodies


Image of a building with the Moderna logo behind a security fence.

Moderna announced Monday that its booster provides protection against COVID-19 variant omicron. In its testing, Moderna found a 50-microgram dose resulted in a 37-fold increase of antibodies compared to vaccinated, unboosted individuals. 

A 100 µg dose, which is the same amount used in the first two vaccine doses, provided even more protection, increasing antibody levels 83-fold. But that increased immune response was paired with slightly worse side effects than with the smaller dose. 

Moderna’s data is preliminary and has not been reviewed, but CEO Stéphane Bancel said the results are “reassuring” all the same and touted the company’s work on a booster targeted specifically at omicron. “To respond to this highly transmissible variant, Moderna will continue to rapidly advance an Omicron-specific booster candidate into clinical testing in case it becomes necessary in the future. We will also continue to generate and share data across our booster strategies with public health authorities to help them make evidence-based decisions on the best vaccination strategies against SARS-CoV-2.”

Testing was done on the blood of vaccinated people using a pseudovirus engineered to be similar to omicron.

Even though work is being done on vaccines and boosters that specifically target omicron, Moderna’s and Pfizer-BioTech’s current offerings provide strong protection against severe disease caused by the rapidly spreading variant. Data from the UK shows that a third dose of the Pfizer vaccine is 75 percent effective against symptomatic infections from omicron.



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